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. 2021 Nov 27;13(11):1707–1726. doi: 10.4254/wjh.v13.i11.1707

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Graphical summary of Alpers Huttenlocher syndrome and its natural history. BiPAP: Bilevel positive airway pressure; C/I: Contraindicated; CPAP: Continuous positive airway pressure; FTT: Failure to thrive; LTx: Liver transplantation; Mx: Management; PEG: Percutaneous endoscopic gastrostomy; Vx: Vomiting.