Table 2.
Overview of the questionnaires assessing aspects of health-related quality of life in autoimmune hepatitis
|
Questionnaire
|
Main function
|
Domains
|
Items, total score
|
| CFQ[41] | Cognition | Memory, attention, concentration, forgetfulness, word-finding abilities, and confusion | 25 items scored 0-4, total score 0-100 |
| CLDQ[42] | Generic HRQoL | Abdominal symptoms, fatigue, systemic symptoms, activity, emotions, and worry | 29 items scored 1-7, total score 29-203 |
| ECR[43] | Relationship styles | ECR-anxiety, and ECR-avoidance | 12 items scored 1-7, each scale total score 7-42 |
| EQ-5D-5L/EQ-5D-3L/EQ-VAS[44] | Generic HRQoL, EQ-VAS: participants’ self-rated health on a visual analog scale | Mobility, self-care, usual activities, pain/discomfort, and anxiety/depression | EQ-5D: 5 items scored 1-5, total score 5-25; EQ-VAS: total score 0-100 |
| FACIT-F[45] | Fatigue | Physical well-being, social well-being, emotional well-being, functional well-being, and a fatigue-specific domain | 40 items scored 0-4, total score 0-160 |
| FIS[46] | Fatigue | Cognitive functioning, physical functioning, and psychosocial functioning | 40 items scored 0-4, total score 0-160 |
| GAD-7[47] | Anxiety | - | 7 items scored 0-3, total score 0-21 |
| HADS[48] | Anxiety, depression | Anxiety, and depression | 14 items scored 0-3, total score 0-42 |
| LDSI[49] | Liver disease symptoms | Itch, joint pain, abdominal pain, daytime sleepiness, worry about family situation, decreased appetite, depression, fear of complications, and jaundice (+ symptom hinderance) | 18 items scored 1-5, total score 18-90 |
| MFI-20[50] | Fatigue | General fatigue, physical fatigue, reduction in activity, reduction in motivation, and mental fatigue | 20 items scored 1-5, each domain total score 4-20 |
| MFIS[46,51] | Fatigue | Physical, cognitive, and psychosocial functioning | 21 items scored 0-4, total score 0-84 |
| PHQ-9[52] | Depression | Anhedonia, feeling down, sleep, feeling tired, appetite, feeling bad about self, concentration, activity, and suicidality | 9 items scored 0-3, total score 0-27 |
| SF-12[53] | Generic HRQoL | Physical functioning, role limitations due to physical problems, bodily pain, general health, vitality, social functioning, role limitations due to emotional problems, and mental health | 12 items scored 1-5, total score 0-100 |
| SF-36[54] | Generic HRQoL | General health, physical and social functioning, bodily pain, role-physical, mental health, role-emotional, and vitality | 36 items, total score 0-100 |
| STAI[55] | Anxiety | State anxiety, and trait anxiety | 40 items scored 1-4, total score 0-80 |
| WPAI:SHP[56] | Impairment in daily activities and in work | Work productivity impairment, and activity impairment | 6 items scored 0-10, total score - |
Included in the table are the questionnaires that were employed in the reviewed studies. CFQ: Cognitive Failure Questionnaire; CLDQ: Chronic Liver Disease Questionnaire; ECR: Experiences in Close Relationship Scale; EQ-5D-5L/EQ-5D-3L/EQ-VAS: European Quality of life 5-Dimension 5-Level/3-Level/EQ-visual analog scale; FACIT-F: Functional Assessment of Chronic Illness Therapy-Fatigue; FIS: Fatigue Impact Scale; GAD-7: Generalized Anxiety Disorder Screener; HADS: Hospital Anxiety Depression Scale; LDSI: Liver Disease Symptom Index 2.0); MFI-20: Multidimensional Fatigue Index-20; MFIS: Modified Fatigue Impact Scale); PHQ-9: Patient Health Questionnaire; SF-12: Short-form 12; SF-36: Short-form 36; STAI: State-Trait Anxiety Inventory; WPAI:SHP: Work Productivity and Activity-Specific Health Problem).