Table 2.

Root mean square flexibility (RMSF) and average solvent accessibility (SA) values for the putative integrin-binding motifs on the SARS-CoV-2 spike protein receptor-binding domain.

Residue #	Residue	RMSF	Average SA
354	N	0.31	63.18
355	R	0.50	119.18
356	K	0.46	62.27
357	R	0.43	162.45
358	I	0.66	6.82
	Average	0.47	82.78
403	R	0.24	49.09
404	G	0.50	4.18
405	D	1.02	87.27
	Average	0.59	46.85
441	L	1.15	74.00
442	D	0.90	3.18
443	S	1.06	14.64
	Average	1.04	30.61
444	K	1.42	154.45
445	V	2.44	61.55
446	G	2.68	42.73
447	G	1.72	46.45
	Average	2.06	76.30
457	R	0.92	110.73
458	K	1.40	46.91
459	S	1.79	59.45
460	N	1.77	89.82
461	L	1.70	17.00
462	K	2.04	106.36
	Average	1.60	71.71
465	E	1.37	73.64
466	R	0.72	65.09
467	D	1.61	77.64
468	I	1.05	89.82
469	S	1.18	32.27
470	T	1.20	83.55
471	E	1.12	58.45
472	I	1.58	82.82
	Average	1.23	70.41
477	S	3.78	66.45
478	T	3.46	32.09
479	P	4.31	67.09
480	C	5.21	85.73
481	N	5.38	110.45
	Average	4.43	72.36
482	G	5.92	57.36
483	V	5.48	91.36
484	E	5.24	131.27
485	G	4.54	59.82
486	F	3.38	122.55
487	N	2.61	94.27
	Average	4.48	82.57
490	F	0.75	75.09
491	P	0.57	39.64
492	L	0.40	74.82
	Average	0.57	63.18
495	Y	0.45	15.55
496	G	0.45	21.73
497	F	0.37	38.55
	Average	0.42	25.27
502	G	3.99	78.09
503	V	2.80	72.45
504	G	2.05	49.73
505	Y	0.85	103.45
506	Q	0.61	67.91
507	P	0.42	1.09
508	Y	0.21	15.91
	Average (GVG)	2.94	66.76
	Average (VGY)	1.90	75.21
	Average (VGYQPY)	0.83	47.62