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Role of SARS-CoV-2 in the development of cytokine storm (CS): SARS-CoV-2 through activation of CD147 activate myeloid differentiation 88 (MyD88), through toll-like receptor 4 (TLR4) and ACE2 activate angiotensin II (AngII) that together trigger NF-κB pathway, which stimulates the release of pro-inflammatory pathway and development of cytokine storm.
