Fig. 1. Chemical structure, MDM2/4 TR-FRET IC50 data, and SJSA EC50 cell data of macrocyclic peptide CMR19 identified from in vitro selection and of the inactive (B11A) mutant MMS95. Blue color indicates non-natural amino acids in the hit sequence and red color indicates terminal Gly used as spacer for attachment of cell penetrating moieties.
