Table 1.
Availability of summary statistics and number of statistical tests performed in sequencing versus array-based GWASs
| Single-variant array, % (n) | Single-variant sequencing, % (n) | Aggregate sequencing, % (n) | |
|---|---|---|---|
| Summary statistics available without restriction | 12 (300) | 5 (4) | 7 (7) |
| Number of tests (reporting) | |||
| Reported | 91 (5,817) | 74 (61) | 81 (84) |
| Not reported | 9 (610) | 26 (21) | 19 (20) |
| Number of tests (distribution) | overall | overall | overall |
| Minimum | 12,033 | 26,011 | 339 |
| Q1 | 899,892 | 144,477 | 16,788 |
| Median | 5,554,549 | 548,889 | 18,665 |
| Q3 | 9,334,585 | 8,752,596 | 20,843 |
| Maximum | 90,000,000 | 32,503,121 | 129,820,320 |
| WES only | WES only | ||
| Minimum | – | 26,011 | 735 |
| Q1 | – | 81,843 | 16,751 |
| Median | – | 158,091 | 18,360 |
| Q3 | – | 235,133 | 20,000 |
| Maximum | – | 1,810,198 | 88,183 |
| WGS only | WGS only | ||
| Minimum | – | 658,234 | 339 |
| Q1 | – | 7,666,134 | 19,903 |
| Median | – | 12,210,410 | 32,316 |
| Q3 | – | 29,880,479 | 1,082,577 |
| Maximum | – | 32,503,121 | 129,820,320 |
Publications that state that they share summary statistics openly (not including those provided with restricted access). Reported/not reported refers to whether the number of statistical tests performed was detailed in the publication. The number of statistical tests performed in sequencing-based studies is based on publications that provide one “number of statistical tests” (n = 51 of 79 for single-variant analysis, n = 56 of 101 for aggregate analysis). Publications that provide a range of statistical test numbers performed are included in the “reported” category but are not included in the distribution. The data for array-based GWAS were obtained from 2014–2019 studies in the GWAS Catalog (December 2, 2020 release) (see STAR Methods).