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. 2021 Nov 17;12:727475. doi: 10.3389/fgene.2021.727475

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Copyright © 2021 Zou, Wang, Wang, Xiao, Yao, Zeng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MR analyses causal effect estimates for associations between childhood obesity with IS and its subtypes. CI, confidence interval; IVW, inverse-variance-weighted; MR, Mendelian randomization; OR, odds ratio; SNP, single nucleotide polymorphism; IS, ischemic stroke; LAS, large vessel ischemic stroke; CES, cardioembolic ischemic stroke; SVS, small vessel ischemic stroke; ICH, intracerebral hemorrhage; MR. RAPS, MR-Robust Adjusted Profile Score; MR-PRESSO, MR pleiotropy residual sum and outlier.