Table 3.
Comparison of DCM patients without and with a primary endpoint
| No event (n = 291) | Primary endpoint (n = 59) | p-value | |
|---|---|---|---|
| Age [years] | 51.6 ± 15.2 | 55.2 ± 15.3 | 0.10 |
| Male gender [n] | 214 (73.5%) | 45 (76.3%) | 0.66 |
| Weight [kg] | 80.5 ± 16.0 | 76.4 ± 14.0 | 0.07 |
| Height [cm] | 176.0 ± 8.9 | 174.8 ± 11.1 | 0.44 |
| BMI [kg/m2] | 25.9 ± 4.4 | 24.9 ± 3.4 | < 0.05 |
| Heart rate [1/min] | 70.8 ± 15.2 | 74.4 ± 15.0 | 0.09 |
| Atrial fibrillation [n] | 46 (15.8%) | 11 (18.6%) | 0.58 |
| NYHA class [n] | |||
| I | 72 (24.7%) | 12 (20.3%) | 0.50 |
| II | 133 (45.7%) | 19 (32.2%) | 0.08 |
| III | 80 (27.5%) | 28 (47.5%) | < 0.01 |
| IV | 6 (2.1%) | 0 | – |
| Cardiovascular risk factors [n] | |||
| Arterial hypertension | 127 (43.6%) | 27 (45.8%) | 0.75 |
| Dyslipidemia | 76 (26.1%) | 13 (22.0%) | 0.51 |
| Diabetes | 31 (10.7%) | 11 (18.6%) | 0.14 |
| Smoker | 119 (40.9%) | 21 (35.6%) | 0.50 |
| Family history of CAD | 63 (21.6%) | 14 (23.7%) | 0.66 |
| Obesity | 47 (16.2%) | 5 (8.5%) | 0.08 |
| Heart failure therapy [n] | |||
| ACE inhibitor/ARB | 287 (98.6%) | 59 (100.0%) | 0.57 |
| ß-Blocker | 245 (84.2%) | 54 (91.5%) | 0.11 |
| Aldosterone receptor antagonist | 112 (38.5%) | 34 (57.6%) | < 0.01 |
| Loop diuretic | 128 (44.0%) | 42 (71.2%) | < 0.001 |
| Laboratory findings | |||
| Creatinine [mg/dl] | 0.9 (0.8–1.1) | 1.1 (0.9–1.3) | 0.45 |
| NT-pro BNP [ng/l]† | 275.0 (102.3–1229.8) | 1831 (411.3–4976.3) | < 0.05 |
| CMR parameters | |||
| LVEF [%] | 38.2 ± 13.2 | 27.1 ± 12.7 | < 0.001 |
| LVEDV [ml] | 239 ± 81 | 298 ± 133 | < 0.01 |
| LV mass [g] | 139 ± 50 | 189 ± 205 | 0.07 |
| Presence of LGE [n] | 97 (33.3%) | 37 (62.7%) | < 0.001 |
| GLS [%] | − 10.3 ± 4.5 | − 7.5 ± 3.7 | < 0.001 |
| GCS [%] | − 10.0 ± 4.9 | − 6.6 ± 3.6 | < 0.001 |
| GRS [%] | 24.7 ± 12.2 | 17.7 ± 9.4 | < 0.001 |
| Apical rotation [°] | 1.9 ± 4.2 | 2.3 ± 3.9 | 0.36 |
| Basal rotation [°] | − 2.5 ± 3.7 | − 2.3 ± 3.0 | 0.84 |
| LV twist [°] | 5.6 ± 3.1 | 5.0 ± 2.5 | 0.11 |
| LV torsion [°/cm] | 1.2 ± 0.7 | 1.0 ± 0.6 | < 0.05 |
| Normal directed rotation [n] | 159 (54.6%) | 32 (54.2%) | 0.98 |
| Reversed apical rotation [n] | 89 (27.1%) | 15 (25.4%) | 0.84 |
†NT-pro BNP values of 110 patients missing