. Author manuscript; available in PMC: 2022 Jan 15.

Published in final edited form as: Arch Biochem Biophys. 2020 Nov 2;697:108659. doi: 10.1016/j.abb.2020.108659

Table 1.

The impacts of lactate and acidification on immune cells in the TEM

Immune cells	Effects
CD8 T cells	Inhibition of proliferation [48]
	Inhibition of cytokine production/cytotoxicity [12, 48, 201]
	Induction of apoptosis [12, 48]
CD4 T cells	Reduction of the antitumoral Th1 subset [202]
CD4 T cells	Inhibition of motility [201]
Regulatory T cells	Increase of polarization/proliferation [202]
NK cells	Inhibition of cytokine production/effector functions [12, 203]
NK cells	Induction of apoptosis [12]
Dendritic cells	Inhibition of antigen presentation [204]
Dendritic cells	Inhibition of activation [205]
MDSCs	Increase of development/tumor infiltration [203]
MDSCs	Enhancement of immunosuppressive effect [203]
TAMs	Induction of M2 polarization [51, 206]