Figure 2.

Velo1^PLD is enriched with aliphatic and aromatic residues and depleted of small polar residues and has highly clustered aromatic residues. (A) Log₂ of fractions of different amino acids in Velo1^PLD divided by equivalent fractions of the same amino acid across all X. laevis IDRs. (B) Log₂ of fractions of different amino acids in Velo1^PLD divided by equivalent fractions of the same amino acid across human PLDs that undergo liquid–liquid phase separation. (C) Graphical definition of the aromatic clustering parameter. (D) Assessment of aromatic clustering (y-axis) compared with the fraction of aromatic or aliphatic residues (x-axis). Among those of X. laevis PLDs, the clustering score Velo1^PLD (black diamond) is higher than all but one, and among those of the PLDs from PhaseSepDB, the clustering score is higher than all but two.