Table 3. Inhibition Patterns and Constants by the l-Met Analogue l-cLeu^a.

variable substrate	fixed substrate	inhibition pattern	inhibition constant (μM)
l-Met	saturating ATP	C	Kis = 290 ± 30
l-Met	nonsaturating ATP	C	Kis = 160 ± 20
ATP	saturating l-Met	NI	ND
ATP	nonsaturating l-Met	U	Kii = 510 ± 20

^aAt pH 7.5 and 22 °C. Saturating ATP = 1 mM, Nonsaturating ATP = 0.07 mM, saturating l-Met = 0.6 mM, and nonsaturating l-Met = 0.02 mM. C indicates competitive inhibition, NI indicates no inhibition, and U indicates uncompetitive inhibition.