Figure 2.

Metrics of published experimental Toxoplasma gondii DNA vaccine designs by antigen number and subcellular location. (A) Reviewed studies evaluated varying numbers of investigated DNA antigens, with few investigating multiple antigens (i.e., antigen cocktails). (B) Reviewed studies evaluated antigens found in various parasite subcellular locations. (C, D) Antigens found in various subcellular locations demonstrate overlapping levels of efficacy in vivo. MIC = microneme-associated proteins; SAG = surface antigen-associated proteins; GRA = dense granule-associated proteins; ROP = rhoptry-associated proteins.