Table 2.
Univariate and multivariate COX regression analyses for OS of oCRC patients in the training cohort
| Variables | Univariate analysis | p | Multivariate analysis | p | |
|---|---|---|---|---|---|
| HR (95%CI) | HR (95%CI) | ||||
| Sex | Male | 1 | - | ||
| Female | 0.878 (0.428, 1.800) | 0.723 | - | - | |
| Age | <60 | 1 | - | - | |
| ≥60 | 1.555 (0.712, 3.398) | 0.268 | - | - | |
| Obstructive type | Acute complete obstruction | 1 | - | - | |
| Incomplete obstruction | 2.252 (0.307, 16.536) | 0.425 | - | - | |
| Obstructive site | Right colon | 1 | - | - | |
| Left colon | 1.158 (0.518, 2.591) | 0.721 | - | - | |
| Rectum | 1.099 (0.410, 2.942) | 0.851 | - | - | |
| Surgical procedure | Palliative resection | 1 | 1 | ||
| Radical resection | 0.199 (0.094, 0.422) | <0.001 | 0.299 (0.139, 0.643) | 0.002 | |
| T stage | T2+3 | 1 | - | - | |
| T4 | 2.229 (0.304, 16.366) | 0.431 | - | - | |
| N stage | N0 | 1 | 1 | ||
| N1 | 3.820 (1.374, 10.615) | 0.01 | 3.187 (1.137, 8.938) | 0.028 | |
| N2 | 6.582 (2.280, 19.005) | <0.001 | 4.098 (1.393, 12.051) | 0.01 | |
| M stage | M0 | 1 | - | - | |
| M1 | 3.522 (1.714, 7.239) | 0.001 | - | - | |
| TNM stage | I+II | 1 | - | - | |
| III | 6.084 (1.347, 27.475) | 0.019 | - | - | |
| IV | 14.472 (3.326, 62.961) | <0.001 | - | - | |
| Histopathology | Adenocarcinoma | 1 | - | - | |
| Mucinous or signet ring adenocarcinoma | 1.285 (0.571, 2.894) | 0.544 | - | - | |
| WBC (×10^9/L) | <9.5 | 1 | - | - | |
| ≥9.5 | 1.520 (0.619, 3.736) | 0.361 | - | - | |
| NCP (%) | <75% | 1 | - | - | |
| ≥75% | 2.159 (1.052, 4.432) | 0.036 | - | - | |
| HGB (g/L) | ≤120 | 1 | - | - | |
| >120 | 0.617 (0.299, 1.273) | 0.192 | - | - | |
| PLT (×109/L) | <350 | 1 | - | - | |
| ≥350 | 1.043 (0.426, 2.555) | 0.927 | - | - | |
| CEA (ng/ml) | <5 | 1 | 1 | ||
| ≥5 | 4.301 (1.643, 11.259) | 0.003 | 2.872 (1.065, 7.740) | 0.037 | |
| CA19-9 (U/ml) | <27 | 1 | - | - | |
| ≥27 | 2.356 (1.144, 4.852) | 0.02 | - | - | |
| Albumin (g/L) | >40 | 1 | - | - | |
| ≤40 | 0.783 (0.382, 1.602) | 0.502 | - | - | |
| Na (mmol/L) | >137 | 1 | - | - | |
| ≤137 | 1.794 (0.853, 3.775) | 0.123 | - | - | |
| K (mmol/L) | >3.5 | 1 | - | - | |
| ≤3.5 | 1.048 (0.366, 3.005) | 0.93 | - | - | |
| Ca (mmol/L) | >2.11 | 1 | - | - | |
| ≤2.11 | 2.002 (0.818, 4.902) | 0.129 | - | - | |
| Cl (mmol/L) | >99 | 1 | - | - | |
| ≤99 | 1.188 (0.454, 3.107) | 0.726 | - | - | |