Table 2.
Renal infiltrates in patients with or without response to immunosuppression in training cohort
| Variables | Overall (n=418) | Responders (n=265) | Nonresponders (n=153) | P Valuea |
|---|---|---|---|---|
| CD68+ macrophages | ||||
| Glomeruli (cells per glomerulus) | 3.3 (1.5–6.4) | 4.7 (2.7–8.2) | 1.5 (0.7–3.2) | <0.001 |
| I-score of CD68+ cell in glomeruli | 6 (4–8) | 7 (5–9) | 4 (3–6) | <0.001 |
| Tubulointerstitium (cells per 100 μm2) | 2.2 (1.2–4.0) | 2.4 (1.4–4.2) | 1.9 (0.8–3.7) | 0.01 |
| CD206+ macrophages | ||||
| Glomeruli (cells per glomerulus) | 2.4 (1.3–3.9) | 3.3 (2.0–4.8) | 1.4 (0.5–2.4) | <0.001 |
| I-score of CD206+ cell in glomeruli | 5 (3–6) | 6 (4–7) | 4 (2–5) | <0.001 |
| Tubulointerstitium (cells per 100 μm2) | 2.3 (1.4–3.9) | 2.4 (1.6–4.1) | 2.1 (1.4–3.6) | <0.001 |
| CD3+ T lymphocytes | ||||
| Glomeruli (cells per glomerulus) | 1.6 (1.2–2.5) | 1.8 (1.3–2.7) | 1.3 (0.9–2.0) | 0.001 |
| I-score of CD3+ cell in glomeruli | 4 (3–5) | 4 (3–5) | 3 (3–4) | <0.001 |
| Tubulointerstitium (cells per 100 μm2) | 2.3 (1.3–3.6) | 2.5 (1.3–3.8) | 2.2 (1.3–3.3) | 0.01 |
Continuous variables were expressed as median (IQR).
a
Comparing between responders and nonresponders.