Table 3.
Performance of renal infiltrates, clinical data, or MEST-C score for predicting response to immunosuppression
| Variables | AUC (95% Confidence Interval) | ||
|---|---|---|---|
| Training Cohort (n=418) | Validation Cohort (n=203) | ||
| I-score of infiltrates in glomeruli | |||
| CD68+ macrophages | 0.78 (0.74–0.83) | 0.81 (0.74–0.88) | |
| CD206+ macrophages | 0.80 (0.76–0.84) | 0.81 (0.74–0.88) | |
| CD3+ T lymphocytes | 0.64 (0.58–0.70) | 0.62 (0.55–0.70) | |
| Number of infiltrates in glomeruli | |||
| CD68+ macrophages | 0.76 (0.71–0.80) | 0.77 (0.71–0.84) | |
| CD206+ macrophages | 0.76 (0.72–0.81) | 0.77 (0.70–0.84) | |
| CD3+ T lymphocytes | 0.64 (0.60–0.71) | 0.61 (0.54–0.70) | |
| Number of infiltrates in tubulointerstitium | |||
| CD68+ macrophages | 0.57 (0.51–0.62) | 0.53 (0.45–0.61) | |
| CD206+ macrophages | 0.55 (0.50–0.61) | 0.60 (0.52–0.68) | |
| CD3+ T lymphocytes | 0.58 (0.53–0.64) | 0.57 (0.54–0.63) | |
| MEST-C score alone | |||
| M | 0.51 (0.49–0.53) | 0.50 (0.47–0.54) | |
| E | 0.51 (0.48–0.54) | 0.53 (0.46–0.59) | |
| S | 0.50 (0.47–0.54) | 0.51 (0.48–0.54) | |
| T | 0.60 (0.55–0.65) | 0.60 (0.52–0.67) | |
| C | 0.52 (0.48–0.57) | 0.50 (0.43–0.58) | |
| All MEST-C components (five variables) | 0.62 (0.56–0.67) | 0.62 (0.54–0.70) | |
| Clinical data alonea | 0.66 (0.60–0.71) | 0.65 (0.57–0.72) | |
| Combination | |||
| Clinical data and MEST-Ca,b | 0.67 (0.61–0.72) | 0.66 (0.58–0.73) | |
| I-score of CD206+ and CD68+ macrophages | 0.84 (0.81–0.88) | 0.86 (0.81–0.92) | |
| I-score of CD206+ and CD68+ macrophages, clinical data, and MEST-Ca,b | 0.87 (0.84–0.91) | 0.87 (0.82–0.92) | |
M, mesangial hypercellularity; E, endocapillary hypercellularity; S, segmental glomerulosclerosis; C, crescent formation.
a
Clinical data included age, sex, eGFR, proteinuria, and mean arterial pressure at the time of renal biopsy.
b
All five MEST-C components, each as an independent variable, were included in the model.