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. Author manuscript; available in PMC: 2021 Dec 2.
Published in final edited form as: Dev Biol. 2020 Sep 17;468(1-2):80–92. doi: 10.1016/j.ydbio.2020.09.006

Fig. 6.

Fig. 6.

Schematic of the role of Zeb2 in postnatal retinogenesis. (A) BMP- and Notchsignaling act as activators of Id genes and Hes1. Ids and Hes1 selectively inhibit photoreceptor specification, and at high levels globally inhibit neural differentiation and promote Muller glial differentiation. Low or medium levels of Id genes and Hes1 are needed to enable bipolar cell differentiation at the expense of photoreceptors. Zeb2 promotes interneuron differentiation by balancing the level of Id genes and Hes1, directly activating bipolar cell-differentiation genes and inhibiting photoreceptor differentiation. (B) BMP signaling is downregulated in the developing retina after P6. Downregulation of BMP might be needed for the onset of bipolar cell generation. Deletion of Zeb2 increases the expression of BMP target genes, inhibiting bipolar cell differentiation. Later, as BMP activity decreases with time, the levels of BMP target genes become low enough to allow bipolar cell generation. Bipolar cell differentiation is thus delayed, but not abolished, in the Zeb2loxp/loxp;αCre retina.