Table 1.

Advantages and disadvantages of microdialysis and microperfusion

	Microdialysis	Microperfusion
Advantages	Strong literature foundation Able to target specific molecular weights Single pump configuration	Less well characterized Largely avoids biofouling Collects biomarkers of all sizes Simple probe construction Simple sterilization process
Disadvantages	Membrane biofouling Complicated probe construction Lack of commercial membrane sizes Membrane expense Membrane sterilization challenges	Tissue damage at high flow rates Secondary pull pump required