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Phospho-tau and tau oligomers are increased in multiple brain regions of hTau mice. Immunoblot analysis of tau oligomers in (A) cortical, (B) hippocampal, and (C) hypothalamic lysates from 20-week-old WT, TauKO, and hTau mice. Immunoblot analysis of pTauSer199Ser202/TotalTau ratio in (D) cortical (n= 8 WT; 6 hTau), (E) hippocampal (n = 7 WT; 9 hTau), and (F) hypothalamic (n = 6 WT; 6 hTau) lysates from 20-week-old WT, TauKO, and hTau mice.
