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. 2020 Mar 16;250(5):480–495. doi: 10.1002/path.5405

Figure 7.

Figure 7

lncRNAs can promote or protect from cancer and neurodegeneration. (A) NBAT1‐lncRNA promotes neuronal differentiation and prevents neuroblastoma. (B) LINK‐A interacts with PIP3, PC, and AKT, resulting in AKT hyperactivity and drug resistance in breast cancer. (C) BC200 disrupts mRNA delivery and translation at the synapse and leads to neurodegeneration. (D) HTT‐AS controls HTT expression levels. Downregulation of HTT‐AS has been linked to the occurrence of Huntington's disease. Created using BioRender.