Figure 8.

L2/3 pyramidal neurons engage inhibitory plasticity following DREADD-induced chronic silencing in AD but not during the CP. A, Representative mIPSC traces and corresponding waveform averages from the control (CNO) and DREADD (DR + CNO) conditions during CP. B, Same as A, but for adult animals. C, Mean mIPSC amplitude from both conditions for CP and AD, respectively (CP: unpaired t test, p = 0.4351; AD: unpaired t test, p = 0.8868). D, Same as C, but comparing the mean mIPSC frequency (CP: Mann–Whitney U test, p = 0.5978; AD: Mann–Whitney U test, p = 0.0029). Sample sizes: for AD experiments, both conditions, n = 18, 5 animals; for CP experiments, both conditions, n = 20, 5 animals.