Table 10.

Summary of post-wean (weeks 34-78) home cage observations^a

	MIA (n = 14)		Control (n = 14)		MIA vs control estimated difference (SE)	p b
	Mean (SD)	Median [range]	Mean (SD)	Median [range]
Sleepc	0.03 (0.05)	0 [0-0.1]	0.04 (0.03)	0.04 [0-0.1]	−0.07 (0.05)	0.20
Nonsocialc	3.3 (0.6)	3.5 [2.2-4.3]	3.4 (0.6)	3.4 [2.0-4.1]	0.04 (0.04)	0.30
Proximity	4.0 (0.5)	4.0 [3.3-4.7]	3.9 (0.5)	3.8 [3.1-4.8]	0.07 (0.17)	0.68
Contactc	0.5 (0.2)	0.5 [0.1-0.8]	0.5 (0.2)	0.5 [0.1-1.1]	0.01 (0.06)	0.92
Playc	1.0 (0.3)	0.9 [0.5-1.4]	0.9 (0.3)	0.8 [0.5-1.4]	−0.05 (0.04)	0.31
Composite activityc	0.5 (0.3)	0.4 [0.2-1.1]	0.6 (0.3)	0.5 [0.2-1.1]	−0.04 (0.08)	0.67
Composite stereotypiesc	0.2 (0.3)	0.1 [0-0.8]	0.2 (0.3)	0.1 [0-1.0]	0.02 (0.12)	0.87

^aInfants were observed 3 times per week between 27 and 85 weeks. For each animal and each week, behaviors were first averaged over the three observations that were available. Not all animals were observed each week; all animals had data between 34 and 78 weeks, so we then averaged each type of behavior again within animals (from 34 to 78 weeks), to create summary behaviors over the course of the study. To these summary behaviors, we fitted linear mixed-effects models with a fixed effect for group and a random effect for the “play buddy” to account for the fact that animals interacted in pairs and the exhibited behaviors were correlated (Standard error, SE.).

^bFrom linear mixed-effects models.

^cData were square root transformed for the analysis.