Table 3. Characteristics of included studies.
| Inflammatory markers assessed | Types of trauma | Study design | Diagnostic criteria | Illness duration in months ± SD | Blood fraction | N (PTSD, non-PTSD) | Male (%) | Mean age in years ± SD | MDD Comorbidity (PTSD%/ non-PTSD%) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| PTSD | non-PTSD | PTSD | Non-PTSD | |||||||||
| Passos, 201541 | IL-1β, IL-2, IL-2R IL-4, IL-6, IL-6R, IL-8, IL-10, INF-γ, TNF-α, CRP | Mixed | Meta-analysis | -- | -- | -- | -- | -- | -- | -- | -- | -- / -- |
| Vidovic, 201142 | IL-6, TNF-alfa | War trauma | Cohort | DSM-IV and ICD-10 | -- | Serum | 64 (39/25)* | 100% | 100% | 38.5±9.1 | 32.6±8.6 | 0%/0% |
| Spivak, 199743 | IL-1β, IL-2R | War trauma | Cross-sectional | DSM-III-R | 90±82.8 | Serum | 38 (19/19)* | 100% | 100% | 25.3±10.9 | 31.7±10.4 | 0%/0% |
* Trauma-unexposed controls.
CRP = C-reactive protein; DSM = Diagnostic and Statistical Manual of Mental Disorders; ICD = International Classification of Diseases; IL-1β = interleukin-1β; IL-2 = interleukin-2; IL-2R = interleukin-2 receptor; IL-4 = Interleukin-4; IL-6 = interleukin-6; IL-6R = interleukin-6 receptor; IL-8 = interleukin-8; IL-10 = interleukin-10; INF-γ = interferon-gamma; MDD = major depressive disorder; PTSD = post-traumatic stress disorder; TNF-α = tumor necrosis factor-alpha.