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Regulation of p53 activity by the mTOR pathway. The PI3K/AKT/mTOR pathway regulates the activity of p53 at multiple levels, such as translational and post-translational levels, etc. The mTOR pathway is able to either positively or negatively regulate p53 activity in a cell type and stress-dependent manner. See text for details (Red arrow: to promote p53 activity; green arrow: to suppress p53 activity).
