TABLE 2.

p53 regulates the mTOR pathway via microRNAs.

miRNAs	p53-mediated regulation of miRNA	The effects of p53 on miRNA expression	miRNA targets in mTOR signaling	The effects on mTOR signaling	Refs
miR-34	Transcriptional	Upregulation	Unknown	Activation	Hermeking. (2007); Liao et al. (2016)
miR-100	Transcriptional	Downregulation	mTOR	Suppression	Sun et al. (2013); Xu et al. (2013); Zhang et al. (2014a); Ghose and Bhattacharyya (2015)
miR-101	Post-transcriptional	Upregulation	mTOR	Suppression	Lin et al. (2014); Fujiwara et al. (2018)
miR-145	Transcriptional	Upregulation	S6K1	Suppression	Sachdeva et al. (2009); Xu et al. (2012)
miR-149	Transcriptional	Upregulation	AKT1	Suppression	Jin et al. (2011); Zhang et al. (2014b)
miR-155	Transcriptional	Upregulation	Rheb, Rictor, and S6K2	Suppression	Wang et al. (2013); Wan et al. (2014); Wang et al. (2018)
miR-199a-3p	Post-transcriptional	Upregulation	mTOR	Suppression	Fornari et al. (2010); Wang et al. (2012a); Wu et al. (2013)