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. 2021 Dec 2;16(12):e0260029. doi: 10.1371/journal.pone.0260029

Table 1. Differences in OCTA, SD-OCT and BCVA before and each time point after surgery via endoscopic endonasal approach.

Baseline 48 hours 1 year Baseline vs 48 hours Baseline vs 1 year 48 hours vs 1 year
β p-value β p-value β p-value
OCTA parameters (%)
SCP Whole 48.81 ± 4.30 49.68 ± 3.10 54.18 ± 2.71 0.314 0.789 4.350 <0.001* 4.036 0.001*
SCP Parafovea 51.11 ± 7.06 51.37 ± 5.80 56.56 ± 4.71 0.621 0.756 4.371 0.029* 3.750 0.041*
SCP Fovea 22.83 ± 7.72 23.61 ± 5.82 28.56 ± 5.04 0.543 0.330 4.757 0.023* 6.800 0.001*
DCP Whole 51.01 ± 8.65 52.62 ± 7.67 58.31 ± 7.03 1.036 0.694 5.957 0.023* 6.993 0.008*
DCP Parafovea 56.36 ± 6.01 57.34 ± 6.94 58.68 ± 5.42 2.366 0.309 2.964 0.017* 5.300 0.021*
DCP Fovea 41.06 ± 9.94 43.66 ± 8.02 51.37 ± 9.10 2.893 0.304 10.121 <0.001* 7.229 0.010*
RPC Whole 47.22 ± 2.73 50.08 ± 2.66 53.50 ± 3.22 1.950 0.017* 4.500 <0.001* 2.500 0.002*
FAZ area (mm 2 ) 0.296 ± 0.10 0.301 ± 0.14 0.297 ± 0.08 0.016 0.572 0.024 0.413 0.070 0.800
OCT parameters (μm)
GCC average 95.31 ± 8.71 93.81 ± 7.06 103.81 ± 7.73 -2.210 0.005* 4.571 0.007* 6.790 0.017*
RNFL average 97.12 ± 6.15 96.87 ± 8.12 106.18 ± 9.65 -0.570 0.473 6.786 0.005* 7.360 0.002*
BCVA (logMAR) -0.11 ± 0.11 -0.21 ± 0.14 -0.29 ± 0.05 -0.014 0.037* -0.098 0.013* -0.083 0.034*

Data expressed as mean ± standard deviation.

OCTA: Optical Coherence Tomography Angiography; SCP: Superficial Capillary Plexus; DCP: Deep Capillary Plexus; RPC: Radial Peripapillary Capillary; FAZ: foveal avascular zone; OCT: Optical Coherence Tomography; GCC: Ganglion Cell Complex; RNFL: Retinal Nerve Fiber Layer; BCVA: best corrected visual acuity.

*p<0.05.