Fig 4. E. coli induced inflammation in mouse reproductive tissues.

(A) Schematic illustration of mouse reproductive tissues and close-up display of an embryo in the uterine cavity. Reprinted from biorender under a CC BY license, with permission from biorender, original copyright. (B-D, N = 3). Immunohistochemical analysis of cervix collected 6 hr after vaginal administration of 10¹¹ CFU of E. coli. E. coli detected in the cervical sections (B, see white arrow, E. coli positive staining). Infected cervix shows higher expression of TLR-4 (C) and P-NFkB (D) compared to control cervix (Scale bar, 100 μm). The close-up displays the enlarged tissue area marked by white boxes (Scale bar, 50 μm).