Table 2. Association analysis between HIV vaccine knowledge, benefits, barriers, facilitators and motives with willingness to participate in HIV vaccine studies among the RV363 participants, by visit status.
| Willingness to Participate Factors | Total Eligible N = 577 | Visit Status | p-valuea | |
|---|---|---|---|---|
| Screening Visit (n = 430) | Exit Visit (n = 430) | |||
| Purpose of a Vaccine is to prevent illness—n/N (%) | 546 (95) * | 407(95) * | 417 (97) | 0.090 |
| Had any previous information on HIV vaccine research, prior to participation—n/N (%) | 223 (39) | 175 (41) | ||
| Source of Previous information regarding HIV vaccine research—n/N (%) | ||||
| Hospital/clinic/health worker | 43 (7) | 35 (8) | 30 (7) | 0.398 |
| Radio/Tv | 143 (25) | 112 (26) | 113 (26) | 0.917 |
| Friend/relative | 71 (12) | 56 (13) | 42 (10) | 0.016 |
| Internet | 12 (2) | 10 (2) | 30 (7) | <0.001 |
| Poster | 4 (1) | 2 (0) | 22 (5) | <0.001 |
| Learned from a vaccine trial volunteer | 3 (1) | 3 (1) | 4 (1) | 0.706 |
| Research center | 7 (1) | 7 (2) | 24 (6) | 0.002 |
| Personal benefits of participating in Vaccine study- n/N (%) | ||||
| Learn how to avoid risky behavior | 529 (92) | 398 (93) | 352 (82) | <0.001 |
| Feel protected from HIV infection | 531 (92) | 394 (92) | 372 (87) | 0.002 |
| Get free HIV counselling and testing | 496 (86) | 369 (86) | 273 (63) | <0.001 |
| Receive updated information about HIV/AIDS | 368 (64) | 276 (64) | 253 (59) | 0.045 |
| Get small reimbursement | 83 (14) | 67 (16) | 18 (4) | <0.001 |
| Be tested for sexually transmitted infection | 527 (91) | 389 (90) | 311 (72) | <0.001 |
| Receive regular health care related to research | 373 (65) | 289 (67) | 206 (48) | <0.001 |
| Get free pregnancy test every 3 months (N = 275 females) | 195 (71) | 137 (50) | 63 (23) | <0.001 |
| Barriers that could make you not participate in a vaccine study- n/N (%) | ||||
| Fear of needle | 26 (5) | 22 (5) | 23 (5) | 0.847 |
| Fear of getting HIV | 1 (0) | 1 (0) | 5 (1) | 0.103 |
| Fear of side effects | 15 (3) | 10 (2) | 7 (2) | 0.405 |
| Fear of death | 1 (0) | 1 (0) | 2 (0) | 0.564 |
| Fear of fetal abnormalities | 10 (2) | 9 (2) | 7 (2) | 0.480 |
| Time required for visits | 1 (0) | 1 (0) | 8 (2) | 0.008 |
| Fear of testing HIV positive | 1 (0) | 1 (0) | 4 (1) | 0.180 |
| Fear of discrimination | 2 (0) | 2 (0) | 1 (0) | 0.564 |
| How likely would you enroll in research study of a new experimental HIV vaccine if (likelyb)—n/N (%) | ||||
| Required to come every 3 months to study center on a specific day | 571 (99) | 425 (99) | 427 (99) | 1.0000 |
| Required to talk about study experiences with a nurse | 571 (99) | 425 (99) | 427 (99) | 1.0000 |
| Required to test for HIV every 3 months | 569 (99) | 423 (98) | 427 (99) | 0.317 |
| Required to be injected with a HIV study vaccine a few times | 541 (94) | 401 (93) | 422 (98) | 0.706 |
| Required to give blood samples every time that you attend a study visit | 554 (96) | 413 (96) | 422 (98) | 0.564 |
| The center was open for weekend visits | 552 (96) | 409 (95) | 422 (98) | 0.103 |
| Required to use contraceptive during study participation (N = 275 females) | 214 (78) | 153 (56) | 172 (63) | 0.178 |
| Which factors are important for your decision to participate in a study of an experimental HIV vaccine (motives) (importantc)—n/N (%) | ||||
| Helping vaccine research | 548 (95) * | 405 (94) * | 429 (100) | <0.001 |
| Helping fighting HIV/AIDS | 549 (95) * | 408 (95) * | 429 (100) | 0.003 |
| Positive family support | 463 (80) * | 343 (80) * | 426 (99) | <0.001 |
| Meet new people | 488 (85) * | 359 (83) * | 426 (99) | <0.001 |
| Helping the community | 553 (96) * | 408 (95) * | 429 (100) | 0.002 |
| Helping the country | 556 (96) * | 412 (96) * | 430 (100) | 0.002 |
| Helping research of HIV Vaccine | 554 (96) * | 411 (96) * | 429 (100) | 0.007 |
| Perceived as HIV positive | 16 (3) * | 11 (3) * | 237 (55) | <0.001 |
| Perceive as High-risk person for HIV infection | 9 (2) * | 7 (2) * | 233 (54) | <0.001 |
| Unable to have sex intercourse | 19 (3) * | 11 (3) * | 231 (54) | <0.001 |
| People refusing contact | 16 (3) * | 10 (2) * | 227 (53) | <0.001 |
| Preventive vaccine will work—n/N (%) | 573 (99) * | 426 (99) * | 428 (100) | 1.0000 |
a. McNemar’s exact test.
n/N = numbers of participants who answered yes, likely or important/total numbers of participants who answered.
b. Likely = composite of somewhat likely and very likely.
c. Important = composite of important and very important.
* Data missing.