Skip to main content
. 2021 Dec 2;16(12):e0259130. doi: 10.1371/journal.pone.0259130

Fig 1. Green-lipped mussel extract reduced pain in MIA-injected rats.

Fig 1

(A) Schedule of rat experimental procedure is shown by a diagram. (B) Pain was analyzed as the difference between the PWL (left) and PWT (right) in vehicle-treated MIA-induced OA rats, and those given GLME orally. Rats with MIA-induced OA (n = 6 per group) were evaluated to day 21. Nociceptive testing was performed using a dynamic plantar esthesiometer; this is an automated version of the von Frey hair assessment tool. (C) Weight-bearing was examined (n = 6 per group) today 28. Data are presented as the means ± SDs of those of three independent experiments. Significant differences were evident between the vehicle- and GLME-treated groups. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the vehicle-treated group.