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. 2021 Dec 2;16(12):e0260229. doi: 10.1371/journal.pone.0260229

Table 3. Baseline total cholesterol, LDL-C, HDL-C and triglycerides (intercept) and change in LDL-C, HDL-C and triglycerides per year (slope) in the 5-yr cohorts (adjusted*).

    Age range in W1 TC LDL-C
  coeff. SE p-value coeff. SE p-value
Intercept Estimate (mmol/l) 45–49 (ref) 5.64 0.033 <0.001 3.54 0.030 <0.001
Difference compared to reference group 50–54 0.239 0.041 <0.001 0.197 0.037 <0.001
55–59 0.362 0.040 <0.001 0.298 0.036 <0.001
60–64 0.514 0.042 <0.001 0.456 0.037 <0.001
65–69 0.447 0.040 <0.001 0.397 0.036 <0.001
Slope Estimate (mmol/l/year) 45–49 (ref) -0.024 0.004 <0.001 -0.012 0.004 0.020
Difference compared to reference group 50–54 -0.026 0.005 <0.001 -0.021 0.004 <0.001
55–59 -0.047 0.005 0.001 -0.041 0.004 <0.001
60–64 -0.066 0.005 <0.001 -0.054 0.004 <0.001
65–69 -0.071 0.005 <0.001 -0.060 0.004 <0.001
    Age range in W1 HDL-C TG
  coeff. SE p-value coeff. SE p-value
Intercept Estimate (mmol/l) 45–49 (ref) 1.50 1.34 1.34 1.34 0.030 <0.001
Difference compared to reference group 50–54 -0.011 0.091 0.091 0.091 0.037 <0.001
55–59 -0.007 0.150 0.150 0.150 0.036 <0.001
60–64 -0.012 0.154 0.154 0.154 0.037 <0.001
65–69 -0.025 0.163 0.163 0.163 0.036 <0.001
Slope Estimate (mmol/l/year) 45–49 (ref) -0.020 0.013 0.013 0.013 0.004 0.020
Difference compared to reference group 50–54 -0.002 -0.006 -0.006 -0.006 0.004 <0.001
55–59 0.001 -0.015 -0.015 -0.015 0.004 <0.001
60–64 0.002 -0.028 -0.028 -0.028 0.004 <0.001
65–69 0.003 -0.031 -0.031 -0.031 0.004 <0.001

*Adjusted by sex and lipid-lowering treatment.