Table 2. KFDV and AHFV clinical observations.
Pigtailed macaques were observed for clinical signs following sc/iv inoculation of KFDV or AHFV. Some parameters (mucous membrane color, dehydration, breathing quality, CRT, and temperature) were only measured during exams. The presence or absence of a clinical sign are reported as Y (yes) or N (no).
| KFDV 3 (sc/iv) | KFDV 4 (sc/iv) | KFDV 5 (sc/iv) | KFDV 6 (sc/iv) | KFDV 7 (sc/iv) | KFDV 8 (sc/iv) | AHFV 1 (sc/iv) | AHFV 2 (sc/iv) | AHFV 3 (sc/iv) | AHFV 4 (sc/iv) | Frequency (sc/iv) n = 10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Decreased appetite | Severe | Severe | Severe | Severe | Decreased | Severe | Decreased | Decreased | Decreased | Severe | 100% |
| Loss of interest in treats | Y | N | Y | Y | N | Y | N | N | N | Y | 50% |
| Piloerection | Y | N | Y | Y | Y | Y | Y | N | N | Y | 70% |
| Hunched posture | N | Y | Y | Y | Y | N | Y | N | N | N | 50% |
| Loose stool | N | N | N | N | N | N | N | N | N | N | 0% |
| No feces | Y | N | N | N | N | N | N | N | N | N | 10% |
| Clear nasal discharge | N | N | N | Y | N | Y | N | N | N | N | 20% |
| Transient epistaxis | N | D8 heavy epistaxis | Y | Y | Y | Y | Dried blood on nose | Y | Y | N | 80% |
| Unsteady | N | Y | N | N | N | Y | N | N | N | N | 20% |
| Slow and careful movements | N | Y | Y | N | N | Y | Y | N | N | N | 40% |
| Reluctant to move | Y | N | Y | N | N | N | N | N | N | N | 20% |
| Using cage for support | Y | Y | N | N | N | Y | Y | N | N | N | 40% |
| Mucous membranes | bluish D6 | bluish D6-8 | bluish D6, D8 | N | a little blood on gums | D4-7 Muddy | N | N | N | D8 Pale pink muddy | 100% |
| Dehydration | D6 5–8% | N | 5–10% | D4-6 5–8%, D9 8–10% | D9 5–8% | D4-7 5–8% | D6 5–8%, D9 10–12% | D4-9 5–8% | D6-9 10–12% | D4 5–8%, D8 10% | 90% |
| CRT 2 seconds or more | D6, 3 sec. | D8, 2 sec | N | N | N | N | N | N | N | N | 20% |
| Temperature change > 1°C | N | Temp drop 1.6°C D8 | Temp drop 1.7°C D8 | N | Temp drop 1.5°C D9 | N | Temp drop 1.6°C D9 | Temp drop 1.2°C D9 | Temp drop 1.7°C D8 | Temp drop 1.7°C D8 | 70% |
| Flushed Appearance | D6 | N | D6-8 | D6 | N | D6-7 | D6-8 | N | D4-8 | D7-8 pale/green | 70% |
| Mild Facial edema | N | N | N | N | N | N | N | N | Y | N | 10% |
| Other Comments | Liver palpable D6-9 | ||||||||||
| Score 35 | D6 | D8 | D8 | N | N | D7 | D9 | N | N | N | 50% |