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. 2021 Dec 2;16(12):e0260958. doi: 10.1371/journal.pone.0260958

Fig 1. Antiviral efficacy of niclosamide in a trans-well model of human bronchial epithelium infected with SARS-CoV-2.

Fig 1

Effect of niclosamide on the infectious titer on day 2, 3 and 4 (A) and intracellular viral RNA on day 4 (B) in two donors. (C) Effect of niclosamide on relative LDH activity as measure of cytotoxicity. **** = p < 0.0001, ** = p < 0.01, * = p < 0.05; Ordinary Two-Way ANOVA (A) and Ordinary One-Way ANOVA (B, C) with Dunnett’s multiple comparison test. Raw data underlying this figure are shown in S1 Table. Nic = Niclosamide.