Fig 6. Precision summary across variable conditions including within (intra-) and between (inter-) runs, operators, days, instruments, reagent lots and barcodes.

A) TMB precision was assessed using %CV of the TMB score across replicates for samples bordering consensus the TMB-High (>10 Muts/Mb) cut off. B) Imprecision in variant detection assessed using average positive agreement (APA, orange) and average negative agreement (ANA, white) within replicates for all variant classes.