Table 2:
Association between KPDI Index score, non-ART medication count, VACS Index 2.0 score, and all-cause mortality rates in people ageing with and without HIV
| n | KPDI index score | Non-ART medication count | VACS Index 2.0 score | All-cause deaths per 1000 person-years (95% CI) | |
|---|---|---|---|---|---|
| People ageing with HIV | |||||
| No KPDIs | 473 | 0 (0) | 1·09 (0·82) | 49 (15) | 27 (22 to 32) |
| KPDI Index quintile 1 | 1161 | –0·43 (0·43) | 4·57 (2·38) | 48 (14) | 22 (20 to 26) |
| KPDI Index quintile 2 | 3688 | 0·00 (0·03) | 2·15 (1·58) | 47 (14) | 21 (20 to 23) |
| KPDI Index quintile 3 | 2010 | 0·34 (0·19) | 4·34 (2·22) | 52 (15) | 37 (34 to 40) |
| KPDI Index quintile 4 | 1263 | 1·45 (0·54) | 6·56 (2·55) | 54 (15) | 47 (43 to 51) |
| KPDI Index quintile 5 | 591 | 5·02 (2·34) | 9·01 (2·87) | 57 (16) | 63 (56 to 71) |
| People ageing without HIV | |||||
| No KPDI | 7793 | 0 (0) | 1·20 (0·90) | 31 (11) | 17 (16 to 18) |
| KPDI Index quintile 1 | 5832 | –0·44 (0·45) | 4·54 (2·40) | 32 (10) | 15 (14 to 16) |
| KPDI Index quintile 2 | 6816 | 0·01 (0·05) | 2·91 (1·83) | 32 (10) | 19 (18 to 20) |
| KPDI Index quintile 3 | 8503 | 0·35 (0·19) | 4·45 (2·20) | 34 (10) | 27 (26 to 28) |
| KPDI Index quintile 4 | 5816 | 1·47 (0·54) | 6·69 (2·50) | 36 (11) | 41 (39 to 43) |
| KPDI Index quintile 5 | 3170 | 5·46 (3·18) | 9·36 (2·62) | 39 (12) | 76 (72 to 79) |
Data are n, mean (SD), or mean (95% CI). ART=antiretroviral therapy. KPDI=known pairwise drug interaction. VACS= Veterans Aging Cohort Study.