. 2021 Nov 18;11:759497. doi: 10.3389/fonc.2021.759497

Table 1.

Correlation of PD1 and PDL1 gene expression with clinical parameters of lung cancer patients.

Variable		Adenocarcinoma and Squamous cell carcinoma
		PD1						PDL1
		Mean ± SD	Median		P-value ^a	P-value ^b		Mean ± SD	Median			P-value ^a	P-value ^b
Gender	Female	0.86 ± 0.30	0.86		Ref.	Ref.		1.03 ± 0.40	1.02			Ref.	Ref.
	Male	0.98 ± 0.42	0.88		<0.0001	0.0349		1.28 ± 0.56	1.13			<0.0001	<0.0001
Stage	1	1.02 ± 0.39	0.94		Ref.	Ref.		1.21 ± 0.55	1.05			Ref.	Ref.
	2+3+4	0.94 ± 0.37	0.88		0.0042	0.0053		1.11 ± 0.55	1.05			0.0188	0.2115
Histology	Adenocarcinoma	0.93 ± 0.36	0.90		Ref.	Ref.		1.13 ± 0.48	1.04			Ref.	Ref.
	Squamous cell carcinoma	0.94 ± 0.44	0.80		0.7980	0.0034		1.30 ± 0.58	1.16			<0.0001	<0.0001
Relapse	No	0.98 ± 0.39	0.92		Ref.	Ref.		1.22 ± 0.52	1.09			Ref.	Ref.
	Yes	0.90 ± 0.42	0.84		0.1654	0.0544		1.18 ± 0.55	1.09			0.9614	0.7333
Survival	Alive	0.96 ± 0.36	0.94		Ref.	Ref.		1.10 ± 0.51	1.04			Ref.	Ref.
	Dead	1.05 ± 0.40	0.88		0.0011	0.6360		1.29 ± 0.59	1.08			<0.0001	0.0074
		Adenocarcinoma
		PD1						PDL1
Variable		Mean ± SD	Median	P-value ^a			P-value ^b	Mean ± SD		Median	P-value ^a		P-value ^b
Gender	Female	0.87 ± 0.31	0.87	Ref.			Ref.	1.03 ± 0.39		1.02	Ref.		Ref.
	Male	0.99 ± 0.39	0.92	<0.0001			0.0028	1.21 ± 0.53		1.08	<0.0001		<0.0001
Stage	1	0.99 ± 0.37	0.94	Ref.			Ref.	1.15 ± 0.50		1.03	Ref.		Ref.
	2+3+4	0.92 ± 0.32	0.88	0.0164			0.0668	1.06 ± 0.49		1.03	0.0491		0.0422
Relapse	No	0.97 ± 0.36	0.95	Ref.			Ref.	1.16 ± 0.47		1.06	Ref.		Ref.
	Yes	0.90 ± 0.39	0.87	0.0261			0.0126	1.12 ± 0.52		1.06	0.2684		0.6403
Survival	Alive	0.95 ± 0.34	0.96	Ref.			Ref.	1.08 ± 0.46		1.03	Ref.		Ref.
	Dead	1.01 ± 0.38	0.87	0.0674			0.3289	1.21 ± 0.55		1.02	0.0034		0.5328
		Squamous cell carcinoma
		PD1						PDL1
Variable		Mean ± SD	Median	P-value ^a			P-value ^b	Mean ± SD		Median	P-value ^a		P-value ^b
Gender	Female	0.84 ± 0.29	0.80	Ref.			Ref.	1.05 ± 0.46		1.01	Ref.		Ref.
	Male	0.97 ± 0.47	0.80	0.0085			0.5275	1.37 ± 0.59		1.22	<0.0001		<0.0001
Stage	1	1.13 ± 0.44	0.92	Ref.			Ref.	1.42 ± 0.66		1.16	Ref.		Ref.
	2+3+4	0.99 ± 0.43	0.85	0.0211			0.0076	1.21 ± 0.64		1.13	0.0182		0.0490
Relapse	No	0.99 ± 0.47	0.82	Ref.			Ref.	1.38 ± 0.61		1.23	Ref.		Ref.
	Yes	0.91 ± 0.45	0.74	0.1964			0.0567	1.29 ± 0.59		1.22	0.2300		0.3517
Survival	Alive	0.99 ± 0.46	0.90	Ref.			Ref.	1.19 ± 0.69		1.08	Ref.		Ref.
	Dead	1.11 ± 0.43	0.90	0.0678			0.1523	1.41 ± 0.63		1.21	0.0218		0.0411

SD, standard deviation; Ref., reference group.

P value for Independent t-test.

P value for Mann-Whitney U test.

Bold face: statistically significant (P value<0.05).