Table 2.

Cox regression analyses of PD1 and PDL1 gene expression levels at early stage lung cancer patients.

	Adenocarcinoma							Squamous Cell Carcinoma
	Relapse							Relapse
	No	Yes						No	Yes
	Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value			Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value
Univariate							Univariate
PD1 <= 0.88	92 (66.19)	47 (33.81)	0.0228	Ref.			PD1 <= 1.59	46 (62.16)	28 (37.84)	0.0311	Ref.
PD1 > 0.88	195 (77.38)	57 (22.62)		0.62 (0.41 ~ 0.93)	0.0201		PD1 > 1.59	23 (85.19)	4 (14.81)		0.32 (0.11 ~ 0.96)	0.0423
PDL1 <= 0.93	49 (62.82)	29 (37.18)	0.0220	Ref.			PDL1 <= 1.20	26 (57.78)	19 (42.22)	0.0534	Ref.
PDL1 > 0.93	238 (76.04)	75 (23.96)		0.63 (0.39 ~ 1.00)	0.0514		PDL1 > 1.20	43 (76.79)	13 (23.21)		0.45 (0.21 ~ 0.95)	0.0359
Additive model c				0.69 (0.53 ~ 0.91)	0.0076		Additive model c				0.53 (0.32 ~ 0.89)	0.0155
Number of higher expression PD1/PDL1							Number of higher expression PD1/PDL1
0 higher expression gene	31 (55.36)	25 (44.64)	0.0055	Ref.			0 higher expression gene	26 (57.78)	19 (42.22)	0.0522	Ref.
1 higher expression gene	79 (75.24)	26 (24.76)		0.51 (0.28 ~ 0.92)	0.0245		1 higher expression gene	20 (68.97)	9 (31.03)		0.61 (0.27 ~ 1.37)	0.2349
2 higher expression gene	177 (76.96)	53 (23.04)		0.44 (0.26 ~ 0.75)	0.0025		2 higher expression gene	23 (85.19)	4 (14.81)		0.26 (0.08 ~ 0.81)	0.0207
	Outcomes							Outcomes
	Alive	Dead						Alive	Dead
	Number (%)	Number (%)	P-value a	HR (95% CI) b		P-value		Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value
Univariate							Univariate
PD1 <= 0.88	103 (61.31)	65 (38.69)	0.0074	Ref.			PD1 <= 1.59	35 (35.71)	63 (64.29)	0.5017	Ref.
PD1 > 0.88	193 (73.95)	68 (26.05)		0.58 (0.41 ~ 0.82)		0.0023	PD1 > 1.59	12 (44.44)	15 (55.56)		0.63 (0.34 ~ 1.16)	0.1361
PDL1 <= 0.93	65 (60.75)	42 (39.25)	0.0401	Ref.			PDL1 <= 1.20	25 (36.76)	43 (63.24)	0.8548	Ref.
PDL1 > 0.93	231 (71.74)	91 (28.26)		0.61 (0.42 ~ 0.89)		0.0101	PDL1 > 1.20	22 (38.60)	35 (61.40)		0.73 (0.45 ~ 1.18)	0.1937
Additive model c				0.68 (0.54 ~ 0.84)		0.0005	Additive model c				0.78 (0.57 ~ 1.00)	0.0539
Number of higher expression PD1/PDL1							Number of higher expression PD1/PDL1
0 higher expression gene	42 (53.85)	36 (46.15)	0.0062	Ref.			0 higher expression gene	25 (36.76)	43 (63.24)	0.6839	Ref.
1 higher expression gene	84 (70.59)	35 (29.41)		0.49 (0.30 ~ 0.79)		0.0032	1 higher expression gene	10 (33.33)	20 (66.67)		0.85 (0.49 ~ 1.45)	0.5425
2 higher expression gene	170 (73.28)	62 (26.72)		0.43 (0.28 ~ 0.66)		0.0001	2 higher expression gene	12 (44.44)	15 (55.56)		0.59 (0.31 ~ 1.12)	0.1068

HR, Hazard ratio; CI, confidence interval; Ref., reference group.

^aP-value for Fisher exact test.

^bAdjusted for age and gender.

^cTrend test for additive model.

Bold face: statistically significant (P value<0.05).