Table 3.

Cox regression analyses of PD1 and PDL1 gene expression levels at late stage lung cancer patients.

	Adenocarcinoma							Squamous Cell Carcinoma
	Relapse							Relapse
	No	Yes						No	Yes
	Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value			Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value
Univariate							Univariate
PD1 <= 0.82	28 (56.00)	22 (44.00)	0.2276	Ref.			PD1 <= 1.17	25 (54.35)	21 (45.65)	0.0318	Ref.
PD1 > 0.82	43 (45.26)	52 (54.74)		1.27 (0.75 ~ 2.14)	0.3739		PD1 > 1.17	8 (27.59)	21 (72.41)		2.08 (1.07 ~ 4.04)	0.0302
PDL1 <= 1.23	57 (51.82)	53 (48.18)	0.2487	Ref.			PDL1 <= 1.36	25 (56.82)	19 (43.18)	0.0098	Ref.
PDL1 > 1.23	14 (40.00)	21 (60.00)		1.13 (0.65 ~ 1.96)	0.6772		PDL1 > 1.36	8 (25.81)	23 (74.19)		2.39 (1.21 ~ 4.69)	0.0118
Additive model c				1.16 (0.83 ~ 1.63)	0.3932		Additive model c				1.51 (1.07 ~ 2.11)	0.0176
Number of higher expression PD1/PDL1							Number of higher expression PD1/PDL1
0 higher expression gene	25 (53.19)	22 (46.81)	0.1723	Ref.			0 higher expression gene	25 (56.82)	19 (43.18)	0.0152	Ref.
1 higher expression gene	35 (53.03)	31 (46.97)		0.97 (0.55 ~ 1.71)	0.9174		1 higher expression gene	0 (0.00)	2 (100.00)		3.73 (0.83 ~ 16.84)	0.0865
2 higher expression gene	11 (34.38)	21 (65.63)		1.37 (0.71 ~ 2.65)	0.3548		2 higher expression gene	8 (27.59)	21 (72.41)		2.31 (1.16 ~ 4.60)	0.0170
	Outcomes							Outcomes
	Alive	Dead						Alive	Dead
	Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value			Number (%)	Number (%)	P-value a	HR (95% CI) b	P-value
Univariate							Univariate
PD1 <= 0.82	29 (47.54)	32 (52.46)	0.8725	Ref.			PD1 <= 1.17	26 (43.33)	34 (56.67)	0.0002	Ref.
PD1 > 0.82	47 (46.08)	55 (53.92)		0.89 (0.57 ~ 1.40)	0.6177		PD1 > 1.17	2 (6.45)	29 (93.55)		1.87 (1.10 ~ 3.18)	0.0216
PDL1 <= 1.23	62 (48.82)	65 (51.18)	0.3459	Ref.			PDL1 <= 1.36	26 (44.83)	32 (55.17)	0.0001	Ref.
PDL1 > 1.23	14 (38.89)	22 (61.11)		0.90 (0.53 ~ 1.51)	0.6829		PDL1 > 1.36	2 (6.06)	31 (93.94)		2.07 (1.21 ~ 3.53)	0.0079
Additive model c				0.92 (0.68 ~ 1.24)	0.5681		Additive model c				1.41 (1.08 ~ 1.84)	0.0127
Number of higher expression PD1/PDL1							Number of higher expression PD1/PDL1
0 higher expression gene	27 (46.55)	31 (53.45)	0.3607	Ref.			0 higher expression gene	26 (44.83)	32 (55.17)	0.0001	Ref.
1 higher expression gene	37 (51.39)	35 (48.61)		0.82 (0.51 ~ 1.35)	0.4395		1 higher expression gene	0 (0.00)	2 (100.00)		4.68 (1.07 ~ 20.38)	0.0400
2 higher expression gene	12 (36.36)	21 (63.64)		0.86 (0.48 ~ 1.57)	0.6321		2 higher expression gene	2 (6.45)	29 (93.55)		2.00 (1.16 ~ 3.44)	0.0126

HR, Hazard ratio; CI, confidence interval; Ref., reference group.

^aP-value for Fisher exact test.

^bAdjusted for age and gender.

^cTrend test for additive model.

Bold face: statistically significant (P value<0.05).