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. 2021 Nov 18;12:772304. doi: 10.3389/fimmu.2021.772304

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Copyright © 2021 Spaner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schema of the hexosamine biosynthetic pathway (HBP). The amino sugar UDP-GlcNAc is generated in the HBP by combining fructose-6-phosphate, glutamine, nucleotides, and acetyl-CoA. More detailed description of the sequential enzyme reactions in the pathway is provided in the text. O-GlcNAc transferase (OGT) uses UDP-GlcNAc to transfer O-GlcNAc moieties onto target proteins that can be recognized by RL2 antibodies and removed by O-GlcNAse (OGA). OGT and OGA inhibitors mentioned in the text are shown in the yellow boxes.