Figure 2.

Schema of O-GlcNAcylated oncogenic processes in the CLL microenvironment. Major signaling and system modules that drive growth and progression of CLL cells are organized in the boxes along with important auxiliary pathways like cytokine- and AKT-signaling. Genes frequently mutated in CLL are colored in red. Proteins and cells discussed in the text that can be affected by O-GlcNAcylation are indicated by the yellow circled G’s. The figure emphasizes that O-GlcNAcylation increases the tumor-suppressing activity of wild-type p53 but enhances many of the signaling processes that support tumor growth in the presence of mutant p53 and an impaired p53 axis.