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. 2021 Dec 3;9(5):1290–1300. doi: 10.1016/j.gendis.2021.11.007

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — The RBD specific monoclonal antibodies (mAbs) against pseudoviruses. (A) The half-maximal inhibitory concentrations (IC₅₀) representative neutralization curves for tested anti-RBD (receptor-binding domain) monoclonal antibodies (mAbs) against D614G, B.1.1.7 and B.1.617 pseudoviruses. Pseudotypes were incubated with different mAbs dilutions for 60 min at 37 °C, and then were incubated onto 293T-ACE2 cells. Upon 72 h, cells were lysed with passive lysis buffer and the activity of firefly luciferase was analyzed. (B) The IC₅₀ and IC₈₀ were quantitatively analyzed using Graphpad 8.0.