Figure S2.

Kinetics of RBD-binding IgG and IgA responses in the upper and lower airways, related to Figure 3

(A-D) BAL and nasal washes were collected at weeks 6, 25, and 42 post-immunization, and days 2, 4, 7, and 14 post-challenge. B.1.617.2 (A-B) and B.1.351 (C-D) RBD-binding IgG titers in the lower (A, C) or upper airway (B, D). Circles indicate individual NHPs. 4-8 NHPs per group. (A-B) Color-coded lines indicate temporal changes in B.1.617.2 RBD-binding titers for individual NHPs. All animals received mRNA-1273. (C-D) Boxes represent interquartile range with the median denoted by a horizontal line. Dotted lines are for visualization purposes and denote 4-log₁₀ increases in binding titers.

(E-H) BAL and nasal washes were collected at weeks 6, 24, and 42 post-immunization, and days 2, 4, 7, and 14 post-challenge. (E-F) WA1 and (G-H) B.1.617.2 RBD-binding IgA titers in the lower (E, G) or upper airway (F, H). Circles in (E-H) indicate individual NHPs. Boxes represent interquartile range with the median denoted by a horizontal line. Dotted lines are for visualization purposes and denote 2-log₁₀ increases in binding titers. 4-8 NHPs per group.

Statistical analysis in (C-H) shown for mRNA-1273 cohort only.