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. 2021 Dec 3;185(1):113–130.e15. doi: 10.1016/j.cell.2021.12.002

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Figure S4 — Vaccinated NHPs do not mount a primary T cell response to SARS-CoV-2 N peptides following challenge, related to Figure 5

(A-C) BAL fluid was collected at weeks 6, 25, and 42 post-immunization, and days 2, 4, 7, and 14 post-challenge. Lymphocytes in the BAL were stimulated with N peptide pools and responses measured by ICS. (A-B) Percentage of memory CD4⁺ T cells with (A) T_H1 markers (IL-2, TNF, or IFNγ) or (B) T_H2 markers (IL-4 or IL-13) following stimulation. (C) Percentage of CD8⁺ T cells expressing IL-2, TNF, or IFNγ. Circles in (A-C) indicate individual NHPs. Boxes represent interquartile range with the median denoted by a horizontal line. Dotted lines set at 0%. Reported percentages may be negative due to background subtraction. 4-8 NHPs per group. See also Figure S3 for gating strategy.