FIG. 1.

Two steps in recombination in which the Msh2p-Msh3p complex may interact with recombination intermediates. (Left) Msh2p-Msh3p loads onto DSB sites at recessed ends (1) and/or plays an active role in scanning hDNA and interacts with loops formed during pairing of homeologous sequences (2), leading to their rejection from the heteroduplex. (Right) Msh2p-Msh3p binds at the junction of homologous and nonhomologous DNA allowing for cleavage of unpaired tails by Rad1p-Rad10p (3) (adapted from reference 17).