REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
IFP35 neutralizing antibody	This paper	N/A
Bacterial and virus strains
SARS-CoV-2 virus WIV04 strain	Zhou et al., 2020b	N/A
Influenza A virus A/Puerto Rico/8/1934 (H1N1)	Hoffmann et al., 2000	N/A
Biological samples
Human Serum Specimens	Provided by Dr. Xiaoping Chen in Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology	N/A
Mouse Serum Samples	This paper	N/A
Critical commercial assays
Protein G Sepharose beads	GE Healthcare	17-0618-05
Human IFP35 ELISA kit	Aviva Systems Biology	OKEH02088
Human IL-6 ELISA kit	BioLegend	430501
Human TNF ELISA kit	BioLegend	430201
Mouse IFP35 ELISA kit	ELISA Genie	MOFI00328
Mouse TNF ELISA kit	BioLegend	430904
Mouse IL-6 ELISA kit	BioLegend	431304
Experimental models: Cell lines
A549	ATCC	CRM-CRL-185
Vero E6	ATCC®	CRL-1586
MDCK (NBL-2)	ATCC	CCL-34
RAW264.7	ATCC	TIB-71
Experimental models: Organisms/strains
Ifp35−/− mice	Xiahou et al., 2017	N/A
Wild type C57BL/6J mice	Guangdong Medical Laboratory Animal Centre	N/A
hACE2 transgenic mice	Jiang et al., 2020	N/A
SPF chicken embryonic eggs	Guangdong Wens Dahuanong Biotechnology Co., Ltd, Guangdong, China	N/A
BALB/c female mice	Guangdong Medical Laboratory Animal Centre	N/A
Oligonucleotides
SARS-CoV-2 S gene amplified forward primer: 5′-CAATGGTTTAACAGGCAC AGG-3′	Jiang et al., 2020	N/A
SARS-CoV-2 S gene amplified reverse primer: 5′-CTCAAGTGTCT GTGGAT CACG-3′	Jiang et al., 2020	N/A
A/Puerto Rico/8/1934 (H1N1) genome RNA was reverse transcribed with primer AGCA AAAGCAGG	This paper	N/A
PR8 viral NP gene amplified forward primer: 5′-ATCACTCACTGAGTGACATC-3′	This paper	N/A
PR8 viral NP gene amplified reverse primer: 5′-TCGTCCAATTCCACCAATCA-3′	This paper	N/A
Software and algorithms
Prism 9.0	Graphpad	http://www.graphpad-prism.cn/
SPSS	IBM SPSS Statistics for Windows, version 26.0	https://www.ibm.com/analytics/spss-statistics-software
Other
QuantStudio® 5 quantitative PCR	Applied Biosystems	SN: 27257220247
ELISA microplate reader	BioTek Instruments, INC	SN: 1803203