Table 3.

Determinants putatively involved in MDMA-induced hyperthermia or hyponatremia

	Determinant	Result	References
1	Dysregulation of the thermoregulatory system (poikilothermia)	Hyperpyrexia at high ambient temperature	Docherty and Green (2010); Rusyniak et al. (2008)
2	Warm ambient temperature and heavy exercise (vigorous dancing)	Increased heat generation in adipose tissue and skeletal muscles	Mills et al. (2003); Rusyniak et al. (2005)
3	Peripheral vasoconstriction	Reduced peripheral blood flow > lower heat dissipation	Gordon et al. (1991); Pedersen and Blessing (2001)
4	Water management in the body	If dehydrated, less water available for sweating. Dehydration via inhibition of AVP-release by diuretics, like alcohol, caffeine (and MDMA)	Camarasa et al. (2006); Vanattou-Saïfoudine et al. (2012)