Table 1.
Baseline characteristics
| All (n = 1069) | Sapien 3 (n = 288) | Evolut (n = 179) | Acurate Neo (n = 428) | Portico THV(n = 110) | Lotus (n = 64) | p value | |
|---|---|---|---|---|---|---|---|
| Clinical data | |||||||
| Age (years) | 82.8 (79.4–86.1) | 82.8 (78.8–85.9) | 83.0 (79.8–6.8) | 82.4 (79.4–85.7) | 83.3 (80.2–85.8) | 83.0 (80.0–86.7) | 0.52 |
| Female gender (%) | 994 (93) | 264 (91.7) | 168 (93.9) | 398 (93.0) | 106 (96.4) | 58 (90.6) | 0.49 |
| BSA (m2) | 1.7 (1.6–1.8) | 1.7 (1.6–1.8) | 1.7 (1.6–1.8) | 1.7 (1.6–1.8) | 1.7 (1.6–1.8) | 1.7 (1.6–1.8) | 0.22 |
| CAD (%) | 574 (53.8) | 164 (56.9) | 97 (54.2) | 230 (54.0) | 56 (50.9) | 27 (42.9) | < 0.001 |
| COPD (%) | 184 (17.2) | 54 (18.8) | 34 (19.0) | 78 (18.2) | 12 (10.9) | 6 (9.4) | < 0.001 |
| Diabetes (%) | 266 (24.9) | 69 (24.0) | 38 (21.2) | 110 (25.7) | 37 (33.6) | 12 (18.8) | < 0.001 |
| Stroke (%) | 133 (12.4) | 43 (14.9) | 15 (8.4) | 52 (12.1) | 14 (12.7) | 9 (14.1) | < 0.001 |
| STS PROM (%) | 4.5 (3.1–6.5) | 4.5 (3.2–6.6) | 4.7 (3.2–6.5) | 4.4 (3.2–6.5) | 4.9 (3.1–6.6) | 4.0 (3.0–5.2) | 0.33 |
| Echocardiographic and CT data | |||||||
| LVEF < 30% | 708 (66.4) | 180 (62.7) | 133 (74.7) | 294 (68.9) | 74 (67.3) | 27 (42.2) | < 0.001 |
| Stroke volume index (ml/m2) | 48.0 (37.8–66.0) | 46.5 (36.3–61.0) | 41.9 (32.6–47.3) | 56.0 (41.0–69.0) | 57.3 (42.3–5.0) | 41.7 (34.6–52.5) | < 0.001 |
| iEOA (cm2/m2) | 0.4 (0.3–0.5) | 0.4 (0.3–0.5) | 0.4 (0.3–0.5) | 0.4 (0.3–0.5) | 0.4 (0.3–0.4) | 0.4 (0.3–0.5) | 0.34 |
| Mean gradient (mmHg) | 42.0 (32.0–53.0) | 42.0 (31.8–53.0) | 40.0 (32.0–48.0) | 42.0 (32.0–54.0) | 44.0 (32.0–56.0) | 44.0 (33.1–57.0) | 0.12 |
| CT Annulus Area (mm2) | 368.2 (342.0,–383.1) | 376.1 (351.9–386.2) | 359.8 (320.9–379.8) | 368.0 (345.4–382.9) | 361.5 (331.9–380.8) | 370.0 (353.9–388.3) | < 0.001 |
| CT Annulus Perimeter (mm) | 69.4 (67.0–71.0) | 70.0 (68.0–71.2) | 68.4 (64.9–70.1) | 69.5 (67.2–71.0) | 68.8 (66.6–70.7) | 70.0 (68.5–71.3) | < 0.001 |
| AVC calcification (mm3) | 399.0 (227.2–623.7) | 454.5 (272.9–716.8) | 341.0 (190.8–579.7) | 355.8 (177.3–557.5) | 472.7 (271.3–681.5) | 573.3 (297.5–877.7) | < 0.001 |
| LVOT calcification (mm3) | 5.0 (0–35.1) | 10.0 (0–44.2) | 12.1 (0.1–76.7) | 0.4 (0–16.3) | 5.3 (0–32.6) | 22.1 (0.1–82.4) | < 0.001 |
AVC aortic valve complex, BSA body surface area, CAD coronary artery disease, COPD chronic obstructive lung disease, CT computed tomography, iEOA indexed effective orifice area, LVEF left ventricular ejection fraction, LVOT left ventricular outflow tract