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. 2021 Nov 19;11:766072. doi: 10.3389/fonc.2021.766072

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Copyright © 2021 Ye, Liu, Li, Sun, Peng and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The most significantly enriched KEGG pathways between high- and low-risk patients. KEGG: cytokine-cytokine receptor interaction (A); MAPK signaling pathway (B); neuroactive ligand receptor interaction (C); olfactory transduction (D); pathway in cancer (E); regulation of actin cytoskeleton (F). Relationships between the IRRSM and immune cells. The relationships between IRRSM and immune cells infiltration: radar plot (G); dendritic cells activated (H); dendritic cells resting (I); macrophages M0 (J); T cells CD8 (K); B cells naive (L); macrophages M1 (M); macrophages M2 (N); mast cells activated (O); mast cells resting (P); T cells gamma delta (Q).