Table 1.

Inverse correlation between monomeric and hexameric-like Aβ in human CSF samples

Inclusion n°	Classification	Aβ42/Aβ40	Hexameric Aβ/sAPP
1258	Non-AD	0.069	0.079
1506		0.065	0.055
1523	Pre-clinical AD	0.052	0.075
1268		0.080	0.084
1556		0.052	0.092
1272	Symptomatic AD	0.033	0.140
1329		0.039	0.224
1633		0.032	0.143

CSF samples from eight subjects were monitored in this study: patients n° 1258 and 1506 did not exert any AD-related features. Patients n° 1523, 1268, and 1556 were diagnosed with pre-clinical AD and patients n° 1272, 1329, and 1633 with symptomatic AD. Ratios of monomeric Aβ₄₂ over monomeric Aβ₄₀, and of hexameric-like Aβ over soluble APP (sAPP) were obtained from ECLIA and Western blot quantifications, respectively (see Fig. 5). Pearson’s R correlation test: R =  − 0.70 (R-squared = 0,49), p = 0.05