TABLE 1.
Liver Biochemistries for Experimental Mouse Groups
| AST (U/L) |
ALT (U/L) |
Total Serum Bile Acids (µM) |
Total Serum Bilirubin (mg/dL) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Mean ± SEM | P Value vs. DSS-PN | n | Mean ± SEM | P Value vs. DSS-PN | n | Mean ± SEM | P Value vs. DSS-PN | n | Mean ± SEM | P Value vs. DSS-PN | n |
| Chow | 129.9 ± 13.3* | <0.0001 | 23 | 34.1±2.6* | <0.0001 | 23 | 3.30 ± 0.29* | <0.0001 | 25 | 0.063 ± 0.005* | <0.0001 | 11 |
| DSS-chow | 144.3 ± 20.7* | <0.0001 | 25 | 34.5 ± 4.6* | <0.0001 | 23 | 3.10 ± 0.20* | <0.0001 | 25 | 0.085 ± 0.004 | ns | 9 |
| PN | 125.5 ± 26.8* | 0.0048 | 6 | 45.0 ± 12.0 | 0.0185 | 6 | 3.10 ± 0.30* | <0.0001 | 6 | — | — | — |
| DSS-PN | 290.3 ± 25.8 | — | 27 | 66.8 ± 5.8 | — | 25 | 7.28 ± 0.38 | — | 27 | 0.163 ± 0.01 | — | 10 |
| IL-1−/−/chow | 145.0 ± 35.1* | 0.0181 | 6 | 54.0 ± 8.5 | ns | 6 | 4.20 ± 0.42* | <0.0001 | 5 | 0.054 ± 0.00* | <0.0001 | 3 |
| IL-1−/−/DSS-PN | 108.3 ± 9.4* | <0.0001 | 10 | 39.0 ± 4.2 | 0.0092 | 10 | 4.00 ± 0.60* | <0.0001 | 11 | — | — | — |
Note: Values are presented as mean ± SEM.
*
Significantly different from DSS-PN.
Abbreviation: ns, not significant.