Table 2.
Patient Study Characteristics
| All Studies n=161 |
Studies targeting enrollment of traumatic brain injury patients n=70 |
Studies which did not target traumatic brain injury patients n=91 |
|
|---|---|---|---|
| Population Studied, n (%) | |||
| Traumatic Brain Injury | 70 (43.5%) | 70 (100.0%) | 0 (0%) |
| General PICU | 26 (16.2%) | 0 (0%) | 26 (28.6%) |
| Cardiac Arrest | 10 (6.2%) | 0 (0%) | 10 (11.0%) |
| Sepsis | 10 (6.2%) | 0 (0%) | 10 (11.0%) |
| Congenital heart disease | 8 (5.0%) | 0 (0%) | 8 (8.8%) |
| Trauma | 7 (4.4%) | 1 (1.4%) | 6 (6.6%) |
| Acute respiratory failure | 2 (1.2%) | 0 (0%) | 2 (2.2%) |
| Solid organ transplant | 2 (1.2%) | 0 (0%) | 2 (2.2%) |
| Oncology/Bone marrow transplant | 2 (1.2%) | 0 (0%) | 2 (1.2%) |
| Other | 37 (23.0%) | 0 (0%) | 34 (37.4%) |
| Percent Males Enrolled, Median (IQR) | 62.0 (54.7–67.7) | 66.7 (61.6–74.0) | 58.3 (50.5–62.5) |
| Family Members Evaluated, n (%) | |||
| Anya | 18 (11.2%) | 2(2.9%) | 16 (17.6%) |
| Parent/Grandparent | 18 (11.2%) | 2 (2.9%) | 16 (17.6%) |
| Mortality measured during post-discharge follow-up, n (%) | 89 (55.3%) | 35 (50.0%) | 54 (59.3%) |
| Died during post-discharge follow-up, median % (IQR) | 2.4 (0.0–11.8) |
0.0 (0.0–4.4) |
4.1 (0.0–17) |
| Study Locationb, n (%) | |||
| United States | 50 (31.1%) | 26 (37.1%) | 24 (26.4%) |
| Australia | 19 (11.8%) | 6 (8.6%) | 13 (14.3%) |
| United Kingdom | 18 (11.2%) | 5 (7.1%) | 13 (14.3%) |
| Canada | 16 (9.9%) | 2 (2.9%) | 14 (15.4%) |
| Other Europe | 31 (19.2%) | 8 (11.4%) | 23 (25.3%) |
| Other | 47 (29.2%) | 28 (40.0%) | 19 (20.9%) |
| Enrolled sample size, median (IQR) | 58.5 (34–120) | 48 (29.0–85.5) | 71.5 (37.0–150.0) |
| Enrollment rate, median % (IQR) | 94.2 (66.1–100.0) | 100.0 (76.9–100.0) | 84.3 (58.3–100.0) |
| Enrollment rate not specified, n (%) | 31 (19.3%) | 18 (25.7%) | 13 (14.3%) |
| Patients eligible for follow-up at hospital discharge, median (IQR) | 50 (27–118) | 45 (28.0–81.0) | 66.5 (27.0–170.0) |
| Percent assessed at final point, median (IQR) | 90.5 (71.5–100.0) | 95.8 (81.1–100.0) | 82.3 (66.5–98.7) |
| Number of participants assessed at final follow-up, median (IQR) | 45 (21–83) | 40.0 (22.0–69.0) | 50.0 (21.0–114.0) |
| Number of overall health specific instruments per article, median (IQR) | 2 (1–4) | 2 (1–3) | 2 (1–4) |
| Number of instruments per article, n (%) | |||
| 1 | 59 (36.6%) | 34 (48.6%) | 25 (27.5%) |
| 2–4 | 76 (47.2%) | 24 (34.3%) | 52 (57.1%) |
| 5–7 | 11 (6.8%) | 3 (4.3%) | 8 (8.8%) |
| 8–10 | 13 (8.1%) | 7 (10.0%) | 6 (6.6%) |
| >10 | 2 (1.2%) | 2 (2.9%) | 0 (0.0%) |
n (%) is presented for categorical variables and median (interquartile range) is presented for continuous characteristics.
a
No siblings were specifically evaluated in studies measuring overall health.
b
Groups are not mutually exclusive due to inclusion of studies conducted internationally.