Skip to main content
. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Epilepsia. 2021 Oct 7;62(12):3091–3104. doi: 10.1111/epi.17090

Figure 2. OV329 dose-dependently increases the thresholds of intravenous pentylenetetrazole (ivPTZ)-induced seizures.

Figure 2

Effects of 5, 20, and 40 mg/kg OV329 injected intraperitoneally on the thresholds of the ivPTZ-induced (A) first myoclonic twitch and (B) first clonic seizure in rats (n = 8). Treatment effects were further calculated as percent change to the basal seizure threshold for the myoclonic twitch (C) and the clonic seizure (D). Data are expressed as mean+SEM. Statistically significant differences between OV329 and the basal seizure threshold (A, B), and between OV329 and saline as vehicle control (C, D) are indicated by asterisks (one-way mixed-effects model analysis, post-hoc Sidak correction, **P<0.01, ***P<0.001).